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The central goal of Dr. Olivieri's research
program is to determine the molecular structure of proteinaceous domains
that exhibit bioadhesive functionality. Model peptides in the solvated
adsorbed-state can be examined using a combination of biophysical techniques
to monitor the conformational changes that occur upon substrate binding.
Many of the systems under investigation involve peptides/proteins with
a dual function, (1) a reported ability to adsorb to a surface and then
(2) (specifically or non-specifically) attach cells. Since a protein's
conformation determines its biological function(s), complete structural
analysis of these systems would represent a significant accomplishment
enhancing the scientific and technological understanding of the adhesion
process.
Applications of this work to bioengineering and medical/dental The investigator's individual educational plan is consistent with the goals of D'Youville College, which are, to provide a quality liberal arts education of accurate and timely information, while motivating the students to pursue knowledge. The Bioadhesives Research Lab has been funded by the National Science Fundation Grant # 0132823 |
disciplines and potentially society at large might include the regulation
of (a) microbial attachment, (b) blood contact phenomena, (c) protein attachment
to tissues, (d) targeting of molecules to specific body/organ location
[e.g., anticancer drugs], (e) attachment associated with marine environments
and (f) adhesion in a variety of manufacturing processes.